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Although the exact mechanism is unknown, this rise in melanocyte activity has been shown to be stimulated by prostanoids, cytokines, chemokines, and other inflammatory mediators as well as reactive oxygen species that are released during the inflammatory process

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By preventing that breakdown, cGMP levels stay elevated sustaining the erection once it begins

10.1038/342440a0 [DOI] [PubMed] [Google Scholar] Naldini L., Vigna E., Narsimhan R