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doi:10.4103/jrms.JRMS_862_18 De Bruyn E, Gulbis B, Cotton F
Nat Med 30 , 20492057 (2024)
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When caloric restriction is present, mammals synthesise less IGF-1 and its synthesis in the liver is refractory to GH stimulation [128130]
They also have an impact on NAMPT levels 6 , which fluctuate to meet cellular NAD+ demand
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