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Phosphoribosyl diphosphate (PRPP): biosynthesis, enzymology, utilization, and metabolic significance

People taking certain common medications including metformin for blood sugar management and proton pump inhibitors for acid reflux also face increased deficiency risk

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It promotes nucleic acid and protein synthesis more than adenosylcobalamin does

The published rodent literature has not reported overt toxicity at the studied amounts, but the available data are not equivalent to a regulated Phase 1/2 safety database

This makes it particularly relevant in experimental models focused on targeted metabolic processes