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Bei einer Dosierung von 20 mg/kg Krpergewicht sollte eine Mindest-Infusionszeit von 30 Minuten nicht unterschritten werden.As an intravenous infusion, daily doses of up to 20 mg / kg body weight can be administered in a carrier volume of 250 ml and, in particularly stored cases, even higher doses

S., Hsiao, J.-R

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Briefly, proteins were digested overnight at 37C using trypsin (Promega, Madison, WI, USA) at 1:20 (enzyme:protein) ratio in 2 M urea/0.1M Tris pH 8.5, 1 mM CaCl 2 reaction buffer