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It is often referred to as the master antioxidant because it plays a crucial role in protecting cells from oxidative damage and maintaining overall health

[PMC free article: PMC6138918] [PubMed: 30219068] [CrossRef] 9

Exposure to a number of stressors, including electrophiles, reactive oxidative species, heavy metals, and xenobiotics leads to conformational changes in Keap1, enabling stabilization and nuclear accumulation of Nrf2, where it coordinates the expression of multiple cellular defense enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO-1), and key components of the glutathione (GSH) and thioredoxin (TXN) antioxidant systems 2

Graphical abstract Similar content being viewed by others Introduction Delirium is a prevalent neuropsychiatric syndrome characterized by an acute disturbance in attention, cognition, and consciousness [1]

J Biol Chem 278: 21592-21600

Disulfide bonds were reduced with 10 mM dithiothreitol for 45 min at 56 C