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TMZ is the most commonly used chemotherapeutic drug in the post-surgical treatment of GBM, and it directly damages the tumor cells by methylation of the purine base of tumor cells [30,31]

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The genotoxic effect of organic compounds of mercury such as MeHg and dimethyl mercury, which are even postulated to be more toxic than the inorganic contaminants of mercury, in humans was also proved via their induction of structural and numerical chromosomal aberrations in lymphocytes as it was previously elucidated by Betti et al