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ENS structure and neurochemistry resemble that of the CNS, the external connections between CNS and ENS include sympathetic and parasympathetic nerve fibers that directly connect from the hindbrain to the gastrointestinal tract

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Specifically, lipedemarelated fat expansion may be driven more by structural and functional changes of the lymphatic and vascular systems rather than the metabolic dysfunction typically observed in classical obesity

doi: 10.1016/j.drugpo.2014.10.004 21 StriegelHSimonPFrischSRoeckerKDietzKDickhuthHHet al

25,26 We also reported that DT-109 treatment inhibited the progression of hepatic steatosis and fibrosis in nonhuman primates by modulating microbial bile acid metabolism

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