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As seen with other antioxidants in the past, there is some caution as expressed above with lung cancer models, where there may be an increase in proliferation as a result of p53 inhibition or likewise a possible increase in pulmonary hypertension

doi: 10.3389/fgene.2021.624290 102 CollinsBENeulJL

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However, certain conditions may require caution

A series of estradiol conjugates were prepared that were linked to the platinum center through a spacer attached to an N-functionalized 2-aminoalkylpyridyl chelate (Chart 3C)

When caspase-8 activity is inhibited, TRAF2 prompts RIPK1 to bind RIPK3 with the formation of a necrosome complex also known as ripoptosome [209]