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The FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, contraindicating use in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
In another tumour model, STAT5 induced by Bcr-Abl in chronic myeloid leukemia (CML) cells inhibited the expression of Grx1, increasing ROS levels with consequently decrease of cell viability [191]
Protective effects of novel organic selenium compounds against oxidative stress in the nematode Caenorhabditis elegans
In addition, it has been linked to chronic low-grade inflammation
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