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10.1016/j.lfs.2016.01.036 38 LeeM

Clinically defined and diagnosed as having a body mass index (BMI) exceeding 30 kg/m 2 , the condition has rapidly risen in the global human population from 4% in 1975 to an astounding 18% (more than quadruple) in 2016

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4c,d), indicating that LTC 4 activity is mostly intracrine, in contrast with LTC 4 S-generated LTC 4 in mast cells, which mainly acts on external target cells
doi: 10.1016/j.mad.2009.02.004

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