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The success of tirzepatide has validated the multi-agonist approach, driving substantial research and development in this area

Mutant ALS proteins trigger microglial activation, increase the levels of ROS, and induce neurotoxicity (Henkel et al., 2009)
Vitamin B12 is an essential nutrient for making red blood cells and DNA

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High 5-oxoproline levels have also occasionally been reported with toxic acetaminophen levels (with or without acute liver toxicity) (10,19,24,29)
