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Treatment with diiodothyropropionic acid (DITPA), in animal models and humans with inactivation or mutation in the MCT8 gene, results in reduction in serum TSH and serum T 3 , and an improvement in hypermetabolism with weight gain and reduced caloric needs (60, 262)

Moreover, high-dose L-carnitine supplementation completely prevented the reduction in mitochondrial function markers (Figures 5C, D), and ultimately attenuated cytotoxicity (Figure 5E) in lenvatinib-treated C2C12 myocytes

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(2014) 9:e114881

A naturally occurring protective system in urea-rich cells: mechanism of osmolyte protection of proteins against urea denaturation