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However, the results obtained demonstrated that even though the antioxidant inhibited GSH decrement and attenuated the inflammatory response, the skeletal muscle suffered for efficient recovery from the damage, suggesting that blunting the redox-mediated signaling pathways is not beneficial

2003 Sep 19;278(38):36887-96

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Blacher E, Ben Baruch B, Levy A, Geva N, Green KD, Garneau-Tsodikova S, et al

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Consistent with the results from germline XKR8 KO mice challenged with LPS, neutrophil-specific XKR8 KO mice displayed significantly reduced NET formation in the lungs, lower levels of extracellular dsDNA in BALF and mitigated lung injury, despite similar levels of neutrophil infiltration following LPS challenge (Fig