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Introduction The human copper-binding peptide GHK-Cu (glycyl-l-histidyl-l-lysine) is a small, naturally occurring tri-peptide present in human plasma that also can be released from tissues in case of an injury

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Upon reperfusion, the sudden influx of oxygen triggers excessive production of ROSsuch as superoxide anions, hydroxyl radicals, and peroxynitritewhich inflict damage on microvascular structures and mitochondrial membranes [8]

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