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[85] Gardner CD, Oelrich B, Liu JP, et al

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The COX and LOX pathways are the primary routes for metabolizing AA into inflammatory mediators and breaking it down into leukotrienes, prostaglandins, and some peroxides [58]

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Reproductive toxicity studies of acetylcysteine in the rat given oral doses of acetylcysteine up to 1,000 mg/kg (5.2 times the human mucolytic dose) have also been reported in the literature.1 The only adverse effect observed was a slight non-dose-related reduction in fertility at dose levels of 500 or 1,000 mg/kg/day (2.6 or 5.2 times the human mucolytic dose) in the Segment I study

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