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They have demonstrated that two derivatives 7,8,4'-trihydroxyisoflavone and 7,3',4'-trihydroxyisoflavone inhibit tyrosinase by IC 50 value of 11.21 0.8 M and 5.23 0.6 M, respectively, whereas very low inhibition activity was obtained for 6,7,4'-trihydroxyisoflavone, daidzein, glycitein and genistein 257

Upon agonist stimulation, both APP and spinophilin interact with the third intracellular loop of 2A -AR and competitively inhibit -Arr 2 binding to the receptor, attenuating -Arr-dependent endocytosis and desensitization (Wang and Limbird, 2002

Proc R Coll Surgeons, Dublin, Ireland, 2006

2017KY0121), the Youth Science Foundation of Guangxi Medical University (grant no

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