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Finally, long-term safety follow-up (12 months) is essential to assess risks of chronic Nrf2 activation (e.g., cancer progression) or antioxidant interference with physiological ROS signaling, highlighted by the bardoxolone methyl experience in diabetic kidney disease (Nangaku et al., 2020)

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Oral intake only allows you to make use of about 50-60% of a given substance