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This broad therapeutic window suggests the peptide operates differently from conventional medications with narrow dosing requirements

Tendon surgery usually involves two types of procedures, repair, and replacement
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The pathophysiology is still not completely understood as it is a complex disorder of nervous system function including genetic causes and the influence of neuropeptides [263]

Chen CJ, Wu CC, Chang CY, Li JR, Ou YC, Chen WY, et al

doi: 10.1093/jxb/erv562

In this process, excessive degradation of aggrecan and Col II leads to NP dehydration and resorption and a decline in the ability of the cells to resist mechanical loading, thus contributing to IDD progression 92,93
