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Description
A.KolankayaD.BarlasN

PMID 26431397

Low vitamin B12 has recently been linked to chronic migraine, and high homocysteine, with low cofactors and alterations in MTHFR (remember, the one that allowed the passage of THF to M-THF), has been linked to migraine with aura, due to incorrect methionine synthesis, which ultimately leads to an increase in homocysteine, causing an increase in reactive oxygen species (causing oxidative stress)

[ 1] The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601"

The principle is that the splitting energy value systematically decreases with increasing oxidation state: it is approximately 6.0 eV for Mn 2+ and typically ranges from 4.7 to 4.9 eV for Mn 4+ 59

Chanduluru Hemanth Kumar GU, Santha Arcot
