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identified FGF5 as an oncogenic growth factor and its methylation as a predictive marker for definitive chemoradiotherapy (dCRT) sensitivity from 117 ESCC patients, with low methylation linked to poor response (sensitivity 45%, specificity 90%), highlighting its potential clinical utility

Finally, a subset of ZIPs localized to intracellular membranes, such as ZIP7 in the ER, and ZIP9, ZIP11 and ZIP13 in the Golgi and ER, support organelle-specific zinc signaling, although their precise subcompartmental localizations remain areas of active investigation

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Using transcriptomic analysis, we find that activation of the p53p21 pathway down-regulates expression of many genes involved in nucleotide metabolism

Pontrello CG, McWhirt JM, Glabe CG, Brewer GJ

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