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[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Stupnisek M., Franjic S., Drmic D., Hrelec M., Kolenc D., Radic B., Bojic D., Vcev A., Seiwerth S., Sikiric P

Preclinical studies have not identified toxic doses or lethal doses for BPC-157, and researchers reported no teratogenic, genotoxic, anaphylactic, or local toxic effects

The decision to maintain or increase the dose should be based on individual treatment goals, clinical response, and tolerance to adverse effects

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If you skip the 2mg phase entirely and start at 4mg (which some protocols allow), the gastrointestinal side effects are notably more severe, trading impatience now for discomfort later

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