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Several studies implementing similar study designs yielded non-significant findings (Wilkerson et al., 2012)

ROS generated by mitochondria can enter the ER and trigger the unfolded protein response (UPR), which can activate three types of ER transmembrane protein receptors: Protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating transcription factor-6 (ATF-6) and inosital-requiring enzyme-1 (IRE1), which mediate three signaling pathways

Lamanna-Rama N, Romero-Miguel D, Desco M, Soto-Montenegro ML (2022) An update on the exploratory use of curcumin in neuropsychiatric disorders

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Loss of formimidoyltransferase cyclodeaminase (FTCD) stimulates the PPAR and SREBP2 signaling pathways, resulting in lipid buildup and hepatocarcinogenesis [44]