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GPx4 also affects metabolic diseases, such as NAFLD (non-alcoholic fatty liver disease), where cGPx4 protein expression is down-regulated and induces the non-classical transcriptional variant iGPx4, which promotes ferroptosis by interacting with cGPx4 and converting it from an active monomer to an inactive oligomer, and OSA (obstructive sleep apnea), where macrophage-secreted IL6 promotes hepatocyte MARCH3 expression, mediates GPx4 ubiquitination degradation and exacerbates ferroptosis and lipid accumulation

Type II has a deletion in position 358 of T in exon 4, and Type III has an insert in position 138GA of exon 2

Hematol Oncol Clin North Am 2(1):135158 ( PMID: 1963623 ) Neiers F, Jarriault D, Menetrier F, Briand L, Heydel JM (2021) The odorant metabolizing enzyme UGT2A1: immunolocalization and impact of the modulation of its activity on the olfactory response

H 2 S, another gaseous signaling molecule, has been implicated in CRC vascular function, although research remains limited

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doi: 10.1159/000529109 6 CampbellC.McKenneyP