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Alpha Lipoic Acid (ALA) protects against oxidative damage and environmental stressors

E.Abd El-HackM

IGF1R-6 integrin-S100A4 network governs the organ-specific metastasis of chemoresistant epithelial ovarian cancer cells

Chemical research in toxicology 22 , 11061115, doi: 10.1021/tx9000539 (2009)

Analysis of postmortem specimens from subjects with PD revealed that cytoprotective proteins associated with Nrf2 expressions, such as NQO1 and p62, were partially sequestered within Lewy bodies

A second hydrogen peroxide molecule acts as a reducing agent to regenerate the resting state enzyme, producing a molecule of oxygen and water.36 Hydrogen peroxide though at low amounts tends to regulate some physiological processes such as signaling in cell proliferation, cell death, carbohydrate metabolism, mitochondrial function, and platelet activation and maintenance of normal thiol redox-balance,37 however, at high concentrations it has been reported to be very deleterious to cells.38 Hence, the ability of CAT to effectively limit H2O2 concentration in cells underlines its importance in the aforementioned physiological processes as well as being a first line antioxidant defense enzyme