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Interestingly, it can take years for B12 stores to deplete to a point where a deficiency becomes apparent: Vitamin B12 deficiency affects multiple systems, and sequelae vary in severity from mild fatigue to severe neurologic impairment

De beperkingen van deze studie zijn groot: geen vergelijking met placebo, een kleine steekproef en de mogelijkheid dat de kniepijn vanzelf verbeterde

It does not make the research chemical itself illegal to buy for laboratory use, but it signals real caution

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While some patients experience positive results, recovery can involve stiffness, discomfort, or other complications

A long-term longitudinal real-world study
