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FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

GPx1 knockout mice were shown to have improved sensitivity to insulin compared with GPx1 overexpressing mice

BDIX rats with colon tumor xenografts treated with radiation exhibit a GH-induced apoptosis decrease and preferential protection in non-tumor intestinal cells (Morante et al., 2003)
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The relationship between sleep quality and daytime physical and cognitive performance creates a positive feedback loop: better sleep supports improved training capacity and recovery, while appropriate training and hormone optimization enhance sleep quality, collectively contributing to overall health and performance optimization

AFBO can induce oxidative stress, bind to DNA and proteins, and contribute to hepatocarcinoma development by causing mutations in genes such as the p53 tumor suppressor gene [38]

[DOI] [PubMed] [Google Scholar] [17].Wang H, Wang G, Liang Y, et al