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Every cell makes it, and healthy cells keep it within a finely balanced system

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The antioxidant system is likely disturbed in people with depression (100)

In addition, Gpx1 preferentially scavenges H 2 O 2 and Gpx4 is mostly involved in the elimination of lipid hydroperoxides

Highly reactive oxygen-containing molecules such as superoxide (O), hydrogen peroxide (HO), hydroxyl radicals (OH) and peroxyl radicals (OOH) that are by-products of cellular metabolism that at low levels function in cell signalling and immune defence, but when produced in excess result in oxidative stress, damaging cellular structures such as DNA, proteins and lipids