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Published trials used oral doses of 0.25 mg to 30 mg per day and intravenous single doses of 25 to 400 mcg/kg
The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling

Depending on your individual makeup and daily habits, the benefits usually hold for anywhere from a few days to a couple of weeks

People with vitamin B12 deficiency show different recovery times, ranging from days to months before feeling fully well

1994 May;59(5 Suppl):1213S-1222S

Adjustments depend on lab markers and how well your symptoms respond
