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Rhodamine 123 accumulation studies confirmed these findings, showing a 2.41-fold increase in intracellular retention of the dye when nanoparticles were used to deliver Rhodamine

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The authors failed to provide a satisfactory explanation and as a result, the conclusions of the article have been deemed unreliable. A Frontiers spokesperson did not elaborate when The Transmitter asked for more details about the specific issues with the paper

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Whether this novel senolytic can remove senescent chondrocytes, thus finally enhancing the reparative outcome of ACI has not been reported