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Samples of small volume (150-200L) were thawed under strict cooling conditions (+0C to +2C) within 12-15 minutes in an ice-water bath preferentially without agitation

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These changes occurred before the increase in THDA levels, indicating that the loss of BDNF-TrkB signalling and upregulation of GSTO2 happens before the hyperdopaminergic state, as with the Trkb Penk -KO mice, supporting that GSTO2 increase is more likely a cause of neurodegeneration than a consequence of it

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Drug resistance Cell dedifferentiation is one of the signs of tumor progression and promotes resistance to current therapies (Tsoi et al