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Plotnikov, Binding of Glyprolines to L-Arginine Inverts Its Analgesic and Antiagressogenic Effects, Bull

In a randomized placebo-controlled trial in 80 older men with normal hormone levels but symptoms of hypogonadism, 1,666 mg of maca powder three times daily for 12 weeks improved subjective measures of symptoms of male aging, androgen deficiency, prostate symptoms, and sexual function without changing total or free testosterone levels

The immediate and direct introduction of NAD+ into the system can produce rapid and significant therapeutic effects, which may be particularly beneficial for certain medical interventions or rapid detoxification needs

Also broader effects on gene expression beyond just antioxidants

The choice of animal models to explore the in vivo activity of nAbs and their mechanisms of action is an important one and differences between models and conditions can be anticipated