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however, its strong hydrophilicity and poor lipid solubility result in limited bloodbrain barrier (BBB) permeability and suboptimal clinical performance

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It acts locally within the gastrointestinal tract and is the appropriate choice when the clinical goal is gut-specific

Moreover, structural modulation of urease by NAC is evident, as shown by the CD spectra data ( Figure 4 )

Additionally, translating these findings into clinical therapies, such as microbiota-based treatments or lipid-targeting interventions, poses a significant challenge
