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Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ

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The role of oxidative stress in the COVID-19 disease may involve recognition of the viral S-protein by angiotensin converting enzyme-2 (ACE2) receptor and pattern recognition receptors like toll-like receptors 2 and 4, and activation of transcription factors like nuclear factor kappa B, that subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) expression succeeded by ROS production (Kozlov et al., 2021)

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Qualitative and quantitative screening of methanol extract of Vernonia amygdalina (del.) leaf Phytochemical analysis of the extract showed the presence of alkaloids, flavonoids, tannins, cardiac glycoside and terpenoid (Table 2)