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Phytonutrient inhibitors of SARS-CoV-2/NSP5-Encoded Main Protease (Mpro) autocleavage enzyme critical for COVID-19 pathogenesis

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this enzyme is impaired when the NADH: NAD + ratio increases with the reduction of FAO and lipid accumulation (Figure 1), the expression of these proteins is mainly under the control of the same group of transcription factors, namely peroxisome proliferator-activated receptors PPAR-, PPAR-/, and PPAR-

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One paper [26] reviewing diabetic neuropathy included two RCTs [10,28] and concluded that ALC could relief neuropathic pain, while another paper reviewing HIV-associated neuropathy included one RCT [11] and suggested no superiority of ALC to placebo