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CONTRAINDICATIONS: Sensitivity to cobalt and/or vitamin B12 is a contraindication

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Shifts in GABAergic tone in particular can suppress the firing of dopamine neurons in the ventral tegmental area (VTA), which is the origin point of the mesolimbic dopamine pathway that drives reward

doi: 10.1016/j.neuropharm.2019.04.001

NAD+ is a critical coenzyme involved in hundreds of enzymatic reactions including glycolysis, the citric acid cycle, and oxidative phosphorylation, as well as serving as a substrate for NAD+-consuming enzymes including sirtuins, PARPs, and CD38

Look for cloudiness, discoloration, visible particles, or unusual consistency