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Research shows acamprosate is most effective for people who have already stopped drinking and want to maintain abstinence, reducing the protracted withdrawal symptoms that drive relapse in the weeks and months after acute detoxification
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CHB is also characterized by T-cell exhaustion, which is worsened by alcohol and includes up-regulation of PD-1, CTLA-4, and TIM-3 (66), impaired mitochondrial function in T cells (23, 67), and impaired antigen-presenting function of dendritic and Kupffer cells (6870)
