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Interferon alfa therapy causes a dose-related reduction in white blood cell count and absolute CD4+ lymphocyte count, but the percentage of CD4 cells remains essentially unchanged and its use is not associated with the development of opportunistic infections119-122

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It enhanced TGF receptor I expression, leading to increased Smad2 phosphorylation and upregulation of SMA and collagen I expression (Yang, Zhang, et al

It seems unlikely that the true risk from a small congenital naevus will ever be established accurately because of the impossibility of gathering a sufficiently large cohort of patients whose congenital naevi have been left in situ

BMJ Open 4(2):e003973 Carruthers BM et al (2003) Myalgic encephalomyelitis/chronic fatigue syndrome: clinical working case definition, diagnostic and treatment protocols