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Because the stratum corneum is lipid-rich, peptides do not penetrate easily

This study used the NNMTi 5-amino-1-methylquinolinium (5A-M1Q), since our lab has set precedence using this probe molecule for proof-of-concept studies 8

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Usually, subcutaneous injection is adopted, and the dosage and treatment course need to be individualized

Further research is needed to understand its safety in humans.