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fumigatus resulted in a strain with significant defects in conidial germination, polarized hyphal growth, cell wall structure, and asexual development62 and produced a significantly lower mortality rate in a neutropenic murine model of invasive pulmonary aspergillosis.62,258 Fortwendel et al.89 have obtained data suggesting that the Ras and calcineurin pathways act in parallel to regulate cell wall formation and hyphal growth, and additionally, that the calcineurin pathway elements cnaA and crzA play a major role in proper chitin and glucan incorporation into the A

At lower taxonomic levels, HS has been shown to increase the abundance of already largely dominant Lactobacillus genera in the small intestine of ducks, highlighting the lower evenness in microbial species linked to HS previously mentioned in chickens (Tian et al., 2020)

And you do so in a way that impacts a bunch of different tissues

Zhou WC, Qu J, Xie SY, Sun Y, Yao HW

Neurology 73 , 16931698 (2009)

Ann Oncol 1997