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Moreover, non-protein-bound iron may also increase the activity of iron-containing enzymes such as prolyl hydroxylase (PHD)Dependent proteasomal system 23 , which plays a key role in the degradation of hypoxia-inducible factor-1 alpha (HIF-1) 24

Furthermore, sn2-15-hydroperoxy-eicasotetraenoyl-phosphatidylethanolamines (sn2-15-HpETE-PE) generated by 15-LOX phosphatidylethanolamine binding protein-1 (PEBP1) complex can serve as a marker for ferroptosis (Shah et al., 2018)

The expression levels of the 7RA84 , Hsr203J , and Abr17 genes (markers of defense responses and oxidative stress) were also examined

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This elevated free amino acids pool under NP treatment suggests enhanced nitrogen turnover and possible redirection toward metabolic and osmoprotective pathways, including secondary metabolite biosynthesis