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Proc Am Soc Clin Oncol 21:141a, 2002

Immune-based approaches Immune-based therapeutic strategies have been suggested for some patients with BD and MDD, although due to the biological and clinical heterogeneity of these complex disorders, this type of therapy could be considered as a part of personalized approach, beneficiating approximately one in three patients, according to previous studies [333]

These mechanical environments not only regulate the metabolism of the disc tissue itself but also profoundly affect the biological behavior of implanted mesenchymal stem cells (MSCs)

Future research should focus on enhancing bioavailability, personalized nutrition, and large-scale clinical trials to establish optimal dosing and long-term benefits

NICE recommends lifestyle modifications and PDE5 inhibitors such as sildenafil, tadalafil, vardenafil, and avanafil as first-line pharmacological treatments