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Experimental evidence suggests that lignans can penetrate the blood-brain barrier (BBB) and support mitochondrial function in neuronal cells, thereby reducing oxidative stress and neuroinflammation

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Gao F, Hu XF

However, when this role of riboflavin and associated health claims were evaluated by the EFSA 8 for the general population, the expert panel concluded that a cause-and-effect relationship has only been established for dietary intake of riboflavin in the case of contribution to normal skin and mucous membranes and maintenance of normal vision

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The anti-inflammatory activity of melatonin may also involve Sirtuin-1 induction, suppression of NF-B activation, and stimulation of Nrf2 662