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Kutluhan MA, zsoy E, ahin A, rkmez A, Topakta R, Toprak T, et al

In addition, it has been demonstrated that ROS are also actively involved in the formation of NETs [109], autophagy [110,111,112], chemoattraction and activation of the inflammasome [113,114,115], programmed cell death of infected reservoirs [116, 117], antigen presentation, T-helper cell activation and lymphocyte proliferation [118,119,120,121]

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Prior studies have reported increased interaction between glutaraldehyde and HU proteins at concentrations up to 500 ppm 72 , potentially explaining the hindered PCR amplification observed in the Glut-treated samples

This mechanism is likely due to the C-terminal domain of NCOA4 binding to the conserved surface arginine (R23) of FTH1 in phagocytic cells, subsequently facilitating its interaction with autophagosomes and autolysosomes (14)

Beyond these classical mechanisms, bilirubin may fundamentally shape PD risk by orchestrating early embryonic development of dopaminergic neurons through key morphogenic signals, thereby ensuring robust neural circuit formation