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CXCL12/SDF1 binds to CXCR4 and is the only CXC ELR- chemokine that is directly pro-angiogenic and chemotactic, while other chemokines in this group, including CXCL4, CXCL9 CXCL10, CXCL11 and CXCL14 have angiostatic effects [205]

10.1146/annurev-biophys-062920-063704 643 UverskyV
In glaucoma where elevated pressure or ischemia triggers ganglion cell apoptosis, this shifted balance preserves neurons
