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Transitioning to maintenance dosing (0.25mg twice weekly) instead of stopping abruptly sustains 8085% of peak pigmentation indefinitely JAMA Dermatology research found biweekly dosing retained colour for up to 60 days without further loading
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find evidence that late stage, neuronally differentiated MB cells are more common in MBEN than in more aggressive SHH-MB, indicating a potential maturation block in the developmental lineage of these cells
