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In vivo , intraperitoneal administration of the NRF2 activator RTA-408 significantly upregulated NRF2 expression in neurons of SOD1 G93A transgenic mice, which consequently elevated the expression of GSH, SLC7A11, and GPX4, reduced MDA and ROS levels, suppressed neuronal ferroptosis, lipid peroxidation, and mitochondrial injury, and ameliorated weight loss and motor dysfunction in mice ( G93A transgenic mice
10.1016/j.bbrc.2013.09.041 118 MohapatraP.ShriwasO.MohantyS.GhoshA.SmitaS.KaushikS
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10.1126/science.7522345
Mais ce sont surtout ses capacits antioxydantes et rgnratrices qui nous intressent pour la peau
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