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These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism

10.1007/PL00000871 43 PeterzanM

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[DOI] [PubMed] [Google Scholar] 96.Merenlender-Wagner A., Shemer Z., Touloumi O., Lagoudaki R., Giladi E., Andrieux A., Grigoriadis N.C., Gozes I

Larsson M, Rayzman V, Nolte MW et al (2014) A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk

10.2174/1574888x11308020005 8 BeeravoluN.BroughamJ.KhanI.McKeeC.Perez-CruetM.ChaudhryG