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For people with an MTHFR mutation, methylcobalamin (as opposed to other forms of B12) is therapeutic

This glycoprotein has been extensively studied, particularly in MM, leading to the development of several drugs based on monoclonal antibodies targeting CD38, such as daratumumab and isatuximab

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( + ) administration on lipid metabolism in cells and mice

The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

Clair , nephrologist, in a Cleveland Clinic interview [Cleveland Clinic]