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The accumulation of H2O2 and ONOO- can contribute to oxidative and nitrosative stress, potentially leading to cellular damage and immune dysfunction ( Superoxide anions (O2) are primary ROS generated during cellular respiration and various metabolic processes

We therefore hypothesise that the diarrhea seen in these calves is mostly an infectious one

6 Evidence capsules (updates) This section was added to meet the reviewers requests for updates on PD-specific oxidative stress, genetic intersections, human evidence (including PK/safety), and translational quality checkpoints

J Biol Chem 283:2026820276 Dixon DP, Skipsey M, Edwards R (2010) Roles for glutathione transferases in plant secondary metabolism

Gamma-glutamyl transpeptidase elevation is associated with metabolic syndrome, hepatic steatosis, and fibrosis in patients with nonalcoholic fatty liver disease: a community-based cross-sectional study