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Given that the liver serine pool size is larger in mice fed a HF-SAAR diet, a greater amount of exogenous 13 C-serine would need to be taken up by the liver to achieve a similar proportion of 13 C-serine labeling in livers of mice fed a HF-SAAR diet

Ferroptosis was recently implicated as a mechanism of neurodegeneration in Alzheimers Disease [71], and as a mechanism for neuroinflammation in Parkinsons Disease [85,86]